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adedinhavig
Joined: 16 Jun 2011
Posts: 1
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| Posted: Sat Jun 18, 2011 2:22 am Post subject: hemorrhoid treatment |
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| hemroids treatment |
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wrexeffisreni
Joined: 09 Nov 2011
Posts: 4
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| Posted: Tue Nov 22, 2011 4:34 pm Post subject: hemorrhoid treatment |
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VetDermSA
Treatment of Demodicosis – What are the facts?
Recently I have had several queries about treatment options for
demodicosis. Most of these seemed to occur after the visit of a drug rep
promoting a new product.
There are several accepted effective therapies for demodicosis including
Amitraz DemadexВ®, Ivermectin AvomecВ® and Milbemycin oxime
InterceptorВ® but comparison of their relative efficacies is
difficult due to studies being conducted under different conditions and
with varied drug doses. One of the major problems with efficacy studies
is the selection of animals for a treatment. In cases of juvenile onset
demodicosis 90 of localised cases and 30-50 of generalised cases will
self cure, without specific treatment in 6-8 weeks. If these are
included in a study high success rates could be achieved with a placebo.
All treatments of these treatments have similar success rates over 90
for cure but relapses often occur.
In practice the majority of failures when using these drugs relates to
compliance and monitoring issues. The problem usually results from the
fact that clinical cure usually occurs weeks to months before
parasitological cure.
The only licensed product in Australia is amitraz applied weekly as a
250-500 ppm rinse. Unfortunately this is not 100 effective at
eliminating demodex infestations. In North America it is licensed for
fortnightly use at 250 ppm and if used correctly cure rates of 90 are
to be expected. In some studies concentrations of 500 or even 1000 ppm
have been used with increasing effectiveness. If used weekly under the
Australia licensed protocol a higher success rate should be expected.
Even in cases of complete parasitological cure up to 25 of generalised
demodecosis recur within 1 year. Unfortunately amitraz is unpleasant and
labour intensive to use. Owners also need to be warned that they may
have untoward effects if they are not careful to avoid contact with the
solution. These include contact dermatitis, migraine headaches and
asthma attacks. Dogs are often sedated through the action of amitraz on
alpha adrenergic receptors particularly if the skin is damaged but this
can be reversed by using atipamezole AntisedanВ®.
Ivermectin is the most popular unlicensed product for treatment of
demodicosis with numerous references for its use. Cure rates |
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